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Beilstein J. Org. Chem. 2015, 11, 659–667, doi:10.3762/bjoc.11.74
Graphical Abstract
Figure 1: N-Bu DNJ (1) and examples of potent multivalent pharmacological chaperones and CFTR correctors (2 a...
Figure 2: Azide-armed DNJ derivatives 4 and polyalkyne “clickable” scaffolds 5 and 6.
Scheme 1: Synthesis of trisubstituted BODIPY derivatives. (a) ICl, CHCl3/MeOH, rt, 15 min, quantitative; (b) ...
Scheme 2: Synthesis of DNJ clusters 13: (a) CuSO4·5H2O cat., sodium ascorbate, THF/H2O (1:1), 83% (12a), 56% (...
Scheme 3: Synthesis of DNJ clusters 15: (a) CuSO4·5H2O cat., sodium ascorbate, DMF/H2O (6:1), 80 °C (MW) or r...
Figure 3: a) Absorption (orange line), corrected emission (green line) (λexc = 510 nm), excitation (dashed bl...
Figure 4: a) Absorption (orange line), corrected emission (green line) (λexc = 360 nm) and excitation (dashed...